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CERo Therapeutics, Inc. Provides Corporate Update for Shareholders

SOUTH SAN FRANCISCO, Calif., May 15, 2024 (GLOBE NEWSWIRE) -- CERo Therapeutics Holdings, Inc., (Nasdaq:CERO) (“CERo”) an innovative immunotherapy company seeking to advance the next generation of engineered T cell therapeutics that employ phagocytic mechanisms, provides shareholders with a corporate update reviewing activities since its entering the public market.

CERo Chairman and CEO Brian G. Atwood comments, “CERo has undergone significant transformation since the founding of this small private company dedicated to exploring the potential of engineered T cells, to a merger with SPAC Phoenix Biotech Acquisition Corporation, with multiple preclinical milestones along the way.  The June 2023 initiation of the merger, followed by the February 2024 de-SPAC has positioned the Company as an operating Nasdaq-traded entity, which we believe has been in the highest interest of all our various shareholders.  In the meantime we have been diligently completing the pre-clinical studies and documentation tasks necessary to initiate clinical trials after acceptance of an Investigational New Drug Application with the FDA. 

“In March 2024, we announced the  publication of “Therapeutic Targeting of TIM-4-L With Engineered T Cells for Acute Myeloid Leukemia” in Clinical Cancer Research, a journal of the American Association for Cancer Research.  The paper is a composite of preclinical studies analyzing what we established as our lead clinical candidate CER-1236 in targeting Acute Myelogenous Leukemia (AML) tumor cells from human patients, and the candidate’s killing effects on these tumor cells.   These outcomes are a snapshot of a previous paper the Company published in May 2023, “Chimeric TIM-4 receptor-modified T cells targeting phosphatidylserine mediates both cytotoxic antitumor responses and phagocytic uptake of tumor associated antigen for T cell cross-presentation.”  Published in Molecular Therapy, this was the first published review of our mechanism of action, for which the subsequent paper provided additional evidence in another cancer, AML.

“We are now diligently completing our IND-enabling work, from toxicology studies to completing manufacturing runs to meet cGMP standards, all in the interest of submitting an application to the FDA in the near term.  The additional studies will also likely result in submissions to peer reviewed venues such as medical conferences and publications to help gain additional validation of this extensive work.  We anticipate providing status updates to our shareholders, including presentations at upcoming investor conferences,  potential growth of our intellectual property portfolio, and progress on other programs beyond AML, as it is made and through other methods of communication, as appropriate.  In the meantime, we remain grateful to our shareholders and to the scientific community for its embrace of what we believe is game changing science with significant potential to alter the way we treat cancer,” concluded Mr. Atwood.

About CERo Therapeutics, Inc.
CERo is an innovative immunotherapy company advancing the development of next generation engineered T cell therapeutics for the treatment of cancer. Its proprietary approach to T cell engineering, which enables it to integrate certain desirable characteristics of both innate and adaptive immunity into a single therapeutic construct, is designed to engage the body’s full immune repertoire to achieve optimized cancer therapy. This novel cellular immunotherapy platform is expected to redirect patient-derived T cells to eliminate tumors by building in engulfment pathways that employ phagocytic mechanisms to destroy cancer cells, creating what CERo refers to as Chimeric Engulfment Receptor T cells (“CER-T”). CERo believes the differentiated activity of CER-T cells will afford them greater therapeutic application than currently approved chimeric antigen receptor (“CAR-T”) cell therapy, as the use of CER-T may potentially span both hematological malignancies and solid tumors. CERo anticipates initiating clinical trials for its lead product candidate, CER-1236, in 2024 for hematological malignancies.

Forward-Looking Statements
This communication contains statements that are forward-looking and as such are not historical facts. This includes, without limitation, statements regarding the financial position, business strategy and the plans and objectives of management for future operations of CERo. These statements constitute projections, forecasts and forward-looking statements, and are not guarantees of performance. Such statements can be identified by the fact that they do not relate strictly to historical or current facts. When used in this communication, words such as “anticipate,” “believe,” “continue,” “could,” “estimate,” “expect,” “intend,” “may,” “might,” “plan,” “possible,” “potential,” “predict,” “project,” “should,” “strive,” “would” and similar expressions may identify forward-looking statements, but the absence of these words does not mean that a statement is not forward-looking. When CERo discusses its strategies or plans, it is making projections, forecasts or forward-looking statements. Such statements are based on the beliefs of, as well as assumptions made by and information currently available to, CERo’s management.

Actual results could differ from those implied by the forward-looking statements in this communication. Certain risks that could cause actual results to differ are set forth in CERo’s filings with the Securities and Exchange Commission, including its Annual Report on Form 10-K, filed on April 2, 2024, and the documents incorporated by reference therein. The risks described in CERo’s filings with the Securities and Exchange Commission are not exhaustive. New risk factors emerge from time to time and it is not possible to predict all such risk factors, nor can CERo assess the impact of all such risk factors on its business, or the extent to which any factor or combination of factors may cause actual results to differ materially from those contained in any forward-looking statements. Forward-looking statements are not guarantees of performance. You should not put undue reliance on these statements, which speak only as of the date hereof. All forward-looking statements made by CERo or persons acting on its behalf are expressly qualified in their entirety by the foregoing cautionary statements. CERo undertakes no obligation to update or revise publicly any forward-looking statements, whether as a result of new information, future events or otherwise, except as required by law.

Contact:
Brian Atwood
Chief Executive Officer
batwood@cero.bio

Investors:
CORE IR
investors@cero.bio


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