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Bruker Introduces New Mycobacteria and Fungi IVD Solutions for MALDI Biotyper®, and a Novel LiquidArray® Gastrointestinal Syndromic Panel

  • MBT Mycobacteria IVD Kit optimizes sample preparation and comprehensive library of MBT HT Mycobacteria IVD Module
  • MBT HT Filamentous Fungi IVD Module incorporates extensive fungal library with easy and effective sample preparation (MyT)
  • New MBT Compass HT IVD software significantly increases speed for microbial identification, with unique automated self-tuning
  • New LiquidArray® Gastrointestinal PCR Panel detects 26 pathogens causing gastroenteritis, covering bacteria, viruses, parasites and associated toxins

At the 33rd European Congress of Clinical Microbiology & Infectious Diseases (www.eccmid.org), Bruker Corporation (Nasdaq: BRKR) announced its latest innovations for user-friendly, best-in-class diagnostic solutions for routine clinical microbiology and infection diagnostics laboratories.

This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20230414005018/en/

MALDI Biotyper® sirius (Photo: Business Wire)

MALDI Biotyper® sirius (Photo: Business Wire)

1. Bruker introduces fast next-generation MALDI Biotyper® IVD Software

Microbial identification faster than ever: The MBT Compass HT IVD software provides a high sample throughput for microbial identification with time-to-result of ~5 minutes for 96 sample spots. Because of a fast sample target exchange, the MBT system can now analyze up to 600 samples per hour, while covering over 4,600 species in the reference library.

Microbial identification with optimal performance: The new IDealTune™, part of the MBT Compass HT IVD software, provides fully automated tuning of MALDI-TOF parameters within a sample run, delivering consistent data quality without user intervention. This seamless and effortless approach further increases performance, reproducibility, and up-time of the system.

2. Optimizing sample preparation for mycobacteria

As mycobacteria are challenging species in microbiology, an optimized sample preparation protocol is essential for robust results. The new MBT Mycobacteria IVD Kit offers a user-friendly, dedicated sample preparation method for mycobacteria cultivated in liquid as well as on solid media. The inactivation method for safe sample handling does not require boiling, but convenient incubation of the mycobacteria with an inactivation reagent at room temperature.

Dr. Arthur Pranada, Head of the Microbiology Division at MVZ Dr. Eberhard & Partner in Dortmund, stated: “During the last years the number of clinical samples with nontuberculous mycobacteria has increased, and reliable identification is important for an assessment of the clinical significance. The MBT Mycobacteria IVD Kit further simplifies the workflow for identification of nontuberculous mycobacteria by MALDI-TOF MS and reduces hands-on time. During the evaluation in our laboratory more than 96% of mycobacteria from solid and liquid media could be identified at a high-confidence level.”

Identifying challenging filamentous fungi

Identifying molds and multicellular fungi remains one of the most complex aspects of microbiology, because of varying culture conditions and colony morphology. The new MBT HT Filamentous Fungi IVD Module comes with an easy, yet powerful Mycelium Transfer (MyT) sample preparation procedure which together with a comprehensive reference library offers high identification success rates.

3. New LiquidArray® Gastrointestinal PCR Assay for Broad Syndromic Testing

Rapid culture-free pathogen identification: Bruker’s LiquidArray® technology offers rapid, multiplexed PCR pathogen detection for ease of implementation. Launched on the high-precision FluoroCycler® XT thermocycler, LiquidArray® combines innovative probe and thermocycling technologies with results-at-a-glance visualization for the simultaneous analysis of multiple targets from a single sample. The integrated FluoroSoftware® XT-IVD generates easy-to-interpret results, accelerating clinical decisions. The new LiquidArray® Gastrointestinal is a syndromic panel that enables the simultaneous detection of up to 26 pathogens causing gastroenteritis. LiquidArray® Gastrointestinal is validated on the GenoXtract® fleXT which streamlines extraction and PCR. This provides high-throughput clinical laboratories with a fully integrated workflow from sample to result.

Dr. Wolfgang Pusch, President of the Bruker Microbiology & Infection Diagnostics division, commented: “With the introduction of our new IVD workflows, kits, software and reference libraries for mycobacteria and fungi, we further expand the applications of our established MALDI Biotyper® platform. This creates additional value for all current and future customers. The new LiquidArray® Gastrointestinal is a next-generation syndromic panel with amazing pathogen coverage. It is ideal for laboratories which are interested in a broad screening approach to detect most pathogens in one run.”

To see Bruker’s technology in action, visit booth C3-15 at ECCMID 2023, April 15-18 in Copenhagen, DK.

About the Bruker MALDI Biotyper® (MBT) platform

The MBT enables molecular identification of bacteria, yeasts and fungi. Classification and identification of microorganisms is achieved reliably and quickly using a molecular approach based on proteomic fingerprinting by high-throughput MALDI-TOF MS. Applications include clinical routine microbial identification, environmental and pharmaceutical analysis, taxonomical research, food and consumer product safety and quality control, as well as marine microbiology. In many international laboratories, the MBT has replaced classical biochemical testing for bacterial identification due to its accuracy, speed, extensive species coverage, ease of use, minimal sample preparation and cost-effectiveness. MBT products are available in a research use only (RUO) version, as general purpose (GP) version, as the U.S. FDA-cleared MBT CA System, or in an IVD-CE version. The MBT also has IVD medical device registrations in numerous other countries.

About the Bruker LiquidArray® technology

The innovative LiquidArray® technology optimizes asymmetrical multiplex PCR for creating excess single-stranded amplicons with detection by Lights-On/-Off probes that contain a quencher (Lights-Off) or both fluorophore and quencher (Lights-On). If both probes are hybridized in proximity on the amplicon, the quencher of the Lights-Off probe eliminates the fluorescence emitted by the Lights-On probe. During melting curve analysis, Lights-On/-Off probes detach from the amplicon at specific temperatures. In the unbound state, Lights-On probes cannot emit, and as fluorescence is either emitted or suppressed, specific fluorescence signatures are generated by the unique FluoroCycler® XT thermocycler for the LiquidArray® multiplex PCR technology. The LiquidArray® technology supports multiplexed assays where a large number of targets is analyzed simultaneously from single samples. For example, the LiquidArray®-powered, WHO-endorsed FluoroType® MTDBR VER 2.0 assay detects more than 500 genotypes by the combined analysis of up to 45 different mutations in mycobacteria.

About Bruker Corporation (Nasdaq: BRKR)

Bruker is enabling scientists to make breakthrough discoveries and develop new applications that improve the quality of human life. Bruker’s high performance scientific instruments and high value analytical and diagnostic solutions enable scientists to explore life and materials at molecular, cellular and microscopic levels. In close cooperation with our customers, Bruker is enabling innovation, improved productivity and customer success in life science molecular and cell biology research, in applied and pharma applications, in microscopy and nanoanalysis, as well as in industrial applications. Bruker offers differentiated, high-value life science and diagnostics systems and solutions in preclinical imaging, clinical phenomics research, proteomics and multiomics, spatial and single-cell biology, functional structural and condensate biology, as well as in clinical microbiology and molecular diagnostics. For more information, please visit: www.bruker.com.

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