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Seagen to Showcase Data from Growing Oncology Portfolio During Virtual Scientific Program of the 2021 ASCO Annual Meeting

- Data to be Presented Highlight Significant Progress Across Several Tumor Types -

Seagen Inc. (Nasdaq:SGEN) today announced the presentation of new data from its growing pipeline of marketed and investigational therapies at the virtual scientific program of the 2021 American Society of Clinical Oncology (ASCO) Annual Meeting, to be held June 4-8.

“Emerging data and the breadth of our clinical development programs continue to illustrate progress across our oncology portfolio, highlighting the company’s research efforts in multiple cancers with a high unmet need,” said Roger Dansey, M.D., Chief Medical Officer at Seagen. “Notably, we are looking forward to sharing updated results of the EV-103 and EV-201 clinical trials for PADCEV® (enfortumab vedotin-ejfv) in locally advanced or metastatic urothelial cancer and additional data from the HER2CLIMB trial of TUKYSA® (tucatinib) in previously treated HER2+ metastatic breast cancer patients.”

Key data to be presented include:

Abstract Title

Abstract #

Presentation type

Lead Author

PADCEV® (enfortumab vedotin-ejfv)

Study EV-103: Update on durability results and long-term outcome of enfortumab vedotin + pembrolizumab in first line locally advanced or metastatic urothelial carcinoma (la/mUC)

4528

Poster Presentation

T. Friedlander

Enfortumab vedotin in cisplatin-ineligible patients with locally advanced or metastatic urothelial cancer who received prior PD-1/PD-L1 inhibitors: An updated analysis of EV-201 Cohort 2

4524

Poster Presentation

B. McGregor

Quality of life, functioning, and symptoms in patients with previously treated locally advanced or metastatic urothelial carcinoma from EV-301: A randomized Phase 3 trial of enfortumab vedotin vs chemotherapy

4539

Poster Presentation

R. Mamtani

KEYNOTE-B15/EV-304: Randomized Phase 3 study of perioperative enfortumab vedotin plus pembrolizumab versus chemotherapy in cisplatin-eligible patients with muscle-invasive bladder cancer (MIBC)

TPS4587

Poster Presentation

C. Hoimes

TUKYSA® (tucatinib)

Updated results of tucatinib vs placebo added to trastuzumab and capecitabine for patients with pretreated HER2+ metastatic breast cancer with and without brain metastases (HER2CLIMB)

1043

Poster Presentation

G. Curigliano

Pharmacokinetic (PK) analyses in CSF and plasma from TBCRC049, an ongoing trial to assess the safety and efficacy of the combination of tucatinib, trastuzumab and capecitabine for the treatment of leptomeningeal metastasis (LM) in HER2 positive breast cancer

1044

Poster Presentation

E. Stringer-Reasor

SGNTUC-019: Phase 2 basket study of tucatinib and trastuzumab in previously treated solid tumors with HER2 alterations (trial in progress)

TPS3151

Poster Presentation

T. Stinchcombe

HER2CLIMB-04: Phase 2 open label trial of tucatinib plus trastuzumab deruxtecan in patients with HER2+ unresectable locally advanced or metastatic breast cancer with and without brain metastases (trial in progress)

TPS1097

Poster Presentation

I. Krop

A011801 (CompassHER2 RD): Postneoadjuvant T-DM1 + tucatinib/placebo in patients with residual HER2-positive invasive breast cancer

TPS595

Poster Presentation

C. O’Sullivan

ADCETRIS® (brentuximab vedotin)

Brentuximab vedotin with chemotherapy in adolescents and young adults (AYAs) with stage III or IV Hodgkin lymphoma: A subgroup analysis from the Phase 3 Echelon-1 study

7528

Poster Presentation

H. Crosswell

Brentuximab vedotin in combination with lenalidomide and rituximab in subjects with relapsed or refractory diffuse large B-cell lymphoma (DLBCL) (trial in progress)

TPS7571

Poster Presentation

N. Bartlett

Tisotumab vedotin

Tisotumab vedotin vs investigator’s choice chemotherapy in second- or third-Line recurrent or metastatic cervical cancer (innovaTV 301/ENGOT-cx12/GOG 3057, trial in progress)

TPS5596

Poster Presentation

I. Vergote

Early Pipeline

SGNTGT-001: A Phase 1 study of SEA-TGT, an effector-function enhanced monoclonal antibody (mAb), in advanced malignancies (trial in progress)

TPS2657

Poster Presentation

E. Garralda

A Phase 1 study of SGN-B6A, an antibody-drug conjugate targeting Integrin beta-6, in patients with advanced solid tumors (SGNB6A-001, trial in progress)

TPS3144

Poster Presentation

A. Patnaik

About Seagen

Seagen is a global biotechnology company that discovers, develops and commercializes transformative cancer medicines to make a meaningful difference in people’s lives. Seagen is headquartered in the Seattle, Washington area, and has locations in California, Canada, Switzerland and the European Union. For more information on the company’s marketed products and robust pipeline, visit www.seagen.com and follow @SeagenGlobal on Twitter.

Forward-Looking Statements

Certain of the statements made in this press release are forward looking, such as those, among others, relating to the company’s pipeline and the therapeutic potential of PADCEV, TUKYSA, ADCETRIS, tisotumab vedotin, SEA-TGT and SGN-B6A, including their efficacy, safety and potential therapeutic uses. Actual results or developments may differ materially from those projected or implied in these forward-looking statements. Factors that may cause such a difference include without limitation the difficulty and uncertainty of pharmaceutical product development, including the risks that the company may experience delays in its clinical trials or otherwise experience failures or setbacks in its clinical development programs due to lack of efficacy, adverse events or other factors, and that adverse regulatory actions may occur. More information about the risks and uncertainties faced by Seagen is contained under the caption “Risk Factors” included in the company’s Annual Report on Form 10-K for the year ended December 31, 2020 filed with the Securities and Exchange Commission. Seagen disclaims any intention or obligation to update or revise any forward-looking statements, whether as a result of new information, future events or otherwise, except as required by law.

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