SECURITIES AND EXCHANGE COMMISSION

                             WASHINGTON, D.C. 20549

                                  -------------

                                  SCHEDULE 13D*
                                 (Rule 13d-101)

             INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT
            TO RULE 13d-1(a) AND AMENDMENTS THERETO FILED PURSUANT TO
                                  RULE 13d-2(a)

                    Under the Securities Exchange Act of 1934
                              (Amendment No. 1)(1)

                 Charles River Laboratories International, Inc.
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                                (Name of Issuer)

                     Common Stock, $0.01 par value per share
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                         (Title of Class of Securities)

                                    159864107
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                                 (CUSIP Number)

                              Marc Weingarten, Esq.
                            Schulte Roth & Zabel LLP
                                919 Third Avenue
                            New York, New York 10022
                                 (212) 756-2000
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                  (Name, Address and Telephone Number of Person
                Authorized to Receive Notices and Communications)

                                  June 16, 2010
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                          (Date of Event which Requires
                            Filing of This Statement)



         If the filing person has previously filed a statement on Schedule 13G
to report the acquisition that is the subject of this Schedule 13D, and is
filing this schedule because of Rule 13d-1(e), 13d-1(f) or 13d-1(g), check the
following box. [ ]

         NOTE: Schedules filed in paper format shall include a signed original
and five copies of the schedule, including all exhibits. See Rule 13d-7 for
other parties to whom copies are to be sent.

                         (Continued on following pages)

                               (Page 1 of 4 Pages)

--------------------------

(1) The remainder of this cover page shall be filled out for a reporting
person's initial filing on this form with respect to the subject class of
securities, and for any subsequent amendment containing information which would
alter disclosures provided in a prior cover page.

   The information required on the remainder of this cover page shall not be
deemed to be "filed" for the purpose of Section 18 of the Securities Exchange
Act of 1934 ("Act") or otherwise subject to the liabilities of that section of
the Act but shall be subject to all other provisions of the Act (however, see
the Notes)






DOC ID-11199599.2



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CUSIP NO.      159864107           SCHEDULE 13D           PAGE 2 OF 4 PAGES
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    1       NAME OF REPORTING PERSON
            I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

            JANA PARTNERS LLC
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    2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*       (a) [ ]
                                                                    (b) [ ]

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    3       SEC USE ONLY

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    4       SOURCE OF FUNDS*

            AF
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    5       CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDING IS REQUIRED PURSUANT
            TO ITEM 2(d) or 2(e)                                         [ ]

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    6       CITIZENSHIP OR PLACE OF ORGANIZATION

            Delaware
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                         7      SOLE VOTING POWER

                                4,657,695
                      ---------------------------------------------------------
 NUMBER OF               8      SHARED VOTING POWER
 SHARES
BENEFICIALLY                    -0-
  OWNED BY            ---------------------------------------------------------
    EACH                 9      SOLE DISPOSITIVE POWER
 REPORTING
PERSON WITH                     4,657,695
                      ---------------------------------------------------------
                         10     SHARED DISPOSITIVE POWER

                                -0-
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    11      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH PERSON

                                    4,657,695
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    12      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11)
            EXCLUDES CERTAIN SHARES*
                                                                        [ ]
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    13      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

            7.0%
-------------------------------------------------------------------------------
    14      TYPE OF REPORTING PERSON*

            IA
-------------------------------------------------------------------------------
                     * SEE INSTRUCTIONS BEFORE FILLING OUT!





--------------------------                               ----------------------
CUSIP NO.      159864107           SCHEDULE 13D           PAGE 3 OF 4 PAGES
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       The Schedule 13D filed on June 7, 2010 (the "Schedule 13D") by JANA
Partners LLC, a Delaware limited liability company (the "Reporting Person"),
relating to the shares ("Shares") of common stock, $0.01 par value per share, of
Charles River Laboratories International, Inc., a Delaware corporation (the
"Issuer"), is hereby amended as set forth below by this Amendment No. 1 to the
Schedule 13D.


Item 4.   Purpose of Transaction.

Item 4 of the Schedule 13D is being amended and supplemented by the addition of
the following:

            On June 16th, 2010, the Reporting Person sent a letter to James C.
Foster, the Issuer's Chairman, President and Chief Executive Officer, attached
hereto as Exhibit C and incorporated herein by reference.


Item 5.   Interest in Securities of the Company.

Paragraph (c) of Item 5 of the Schedule 13D is hereby amended and restated as
follows:

     (c) There have been no transactions in the Shares effected by the Reporting
Person during the past sixty days.


Item 7.   Material to be Filed as Exhibits.

Item 7 of the Schedule 13D is being amended and supplemented by the addition of
the following:


     3.   Exhibit C: Letter to James C. Foster dated June 16, 2010









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CUSIP NO.      159864107          SCHEDULE 13D            PAGE 4 OF 4 PAGES
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                                   SIGNATURES

        After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.



Dated:  June 16, 2010



                                                JANA PARTNERS LLC

                                                By: /s/ Jennifer Fanjiang
                                                    --------------------------
                                                Name: Jennifer Fanjiang
                                                Title: Deputy General Counsel