The markets closed flat with the Dow slipping 9 points to 22,349 as North Korean leader Kim Jong Un and President Donald Trump continued to trade insults. Nasdaq rose 4 points to 6,426.

On the upside

Credit Suisse analyst Alethia Young lifted her price target on Ascendis Pharma (Nasdaq: ASND) from $30.00 to $50.00.

Marinus Pharmaceuticals (Nasdaq: MRNS) will present at the Cantor Fitzgerald Global Healthcare Conference on Wednesday, September 27, 2017.

Bargain hunters lifted shares of L Brands (NYSE: LB).

On the downside

Compass Minerals International's (NYSE: CMP) Goodrich, Ontario rock salt mine is operating at reduced rates.

Versartis (Nasdaq: VSAR) reported disappointing results from a VELOCITY Phase 3 clinical trial of somavaratan to treat pediatric growth hormone deficiency.

Secoo Holding (Nasdaq: SECO) priced its public offering of 8.5 million American depositary shares at the discounted price of $13.00 per share.

In the broad market, advancing issues outpaced advancers by a margin of nearly 2 to 1 on the NYSE and by nearly 9 to 8 on Nasdaq. The broader S&P 500 added a point to 2,502. Bitcoin dropped $49 to $3,605.