1.
|
Names
of Reporting Persons.
I.R.S.
Identification Nos. of above persons (entities only).
Paolo
Cavazza
|
||
2.
|
Check
the Appropriate Box if a Member of a Group
(See
Instructions)
(a) o
|
||
3.
|
SEC
Use Only
|
||
4.
|
Citizenship
or Place of Organization
Italy
|
||
5.
|
Sole
Voting Power
1,546,870
|
||
Number
of
Shares
Beneficially
|
6.
|
Shared
Voting Power
0
|
|
Owned
by Each
Reporting
Person
With:
|
7.
|
Sole
Dispositive Power
1,546,870
|
|
8.
|
Shared
Dispositive Power
0
|
||
9.
|
Aggregate
Amount Beneficially Owned by Each Reporting Person
1,546,870
|
||
10.
|
Check
box if the Aggregate Amount in Row (9) Excludes
|
||
11.
|
Percent
of Class Represented by Amount in Row (9)
1.6%
(based on 94,774,187 shares of common stock outstanding as of November 7,
2007, as reported in the Issuer’s prospectus supplement filed
with the Securities and Exchange Commission on November, 19,
2007)
|
||
12.
|
Type
of Reporting Person (See Instructions)
IN
|
1.
|
Names
of Reporting Persons.
I.R.S.
Identification Nos. of above persons (entities only).
Claudio
Cavazza
|
||
2.
|
Check
the Appropriate Box if a Member of a Group
(See
Instructions)
(a) o
(b) o
|
||
3.
|
SEC
Use Only
|
||
4.
|
Citizenship
or Place of Organization
Italy
|
||
5.
|
Sole
Voting Power
0
|
||
Number
of
Shares
Beneficially
|
6.
|
Shared
Voting Power
0
|
|
Owned
by Each
Reporting
Person
With:
|
7.
|
Sole
Dispositive Power
0
|
|
8.
|
Shared
Dispositive Power
0
|
||
9.
|
Aggregate
Amount Beneficially Owned by Each Reporting Person
0
|
||
10.
|
Check
box if the Aggregate Amount in Row (9) Excludes
Certain
Shares (See
Instructions)
o
|
||
11.
|
Percent
of Class Represented by Amount in Row (9)
0%
(based on 94,774,187 shares of common stock outstanding as of November 7,
2007, as reported in the Issuer’s prospectus supplement filed
with the Securities and Exchange Commission November 19,
2007)
|
||
12.
|
Type
of Reporting Person (See Instructions)
IN
|
1.
|
Names
of Reporting Persons.
I.R.S.
Identification Nos. of above persons (entities only).
Sigma-Tau
Finanziaria S.p.A.
|
||
2.
|
Check
the Appropriate Box if a Member of a Group
(See
Instructions)
(a) o
(b) o
|
||
3.
|
SEC
Use Only
|
||
4.
|
Citizenship
or Place of Organization
Italy
|
||
5.
|
Sole
Voting Power
0
|
||
Number
of
Shares
Beneficially
|
6.
|
Shared
Voting Power
0
|
|
Owned
by Each
Reporting
Person
With:
|
7.
|
Sole
Dispositive Power
0
|
|
8.
|
Shared
Dispositive Power
0
|
||
9.
|
Aggregate
Amount Beneficially Owned by Each Reporting Person
0
|
||
10.
|
Check
box if the Aggregate Amount in Row (9) Excludes
Certain
Shares (See
Instructions)
o
|
||
11.
|
Percent
of Class Represented by Amount in Row (9)
0%
(based on 94,774,187 shares of common stock outstanding as of November 7,
2007, as reported in the Issuer’s prospectus supplement filed
with the Securities and Exchange Commission November 19,
2007)
|
||
12.
|
Type
of Reporting Person (See Instructions)
CO
|
1.
|
Names
of Reporting Persons.
I.R.S.
Identification Nos. of above persons (entities only).
Sigma-Tau
International S.A.
|
||
2.
|
Check
the Appropriate Box if a Member of a Group
(See
Instructions)
(a) o
(b) o
|
||
3.
|
SEC
Use Only
|
||
4.
|
Citizenship
or Place of Organization
Luxembourg
|
||
5.
|
Sole
Voting Power
0
|
||
Number
of
Shares
Beneficially
|
6.
|
Shared
Voting Power
0
|
|
Owned
by Each
Reporting
Person
With:
|
7.
|
Sole
Dispositive Power
0
|
|
8.
|
Shared
Dispositive Power
0
|
||
9.
|
Aggregate
Amount Beneficially Owned by Each Reporting Person
0
|
||
10.
|
Check
box if the Aggregate Amount in Row (9) Excludes
Certain
Shares (See
Instructions)
o
|
||
11.
|
Percent
of Class Represented by Amount in Row (9)
0%
(based on 94,774,187 shares of common stock outstanding as of November 7,
2007, as reported in the Issuer’s prospectus supplement filed
with the Securities and Exchange Commission November 19,
2007)
|
||
12.
|
Type
of Reporting Person (See Instructions)
CO
|
1.
|
Names
of Reporting Persons.
I.R.S.
Identification Nos. of above persons (entities only).
Sigma-Tau
America S.A.
|
||
2.
|
Check
the Appropriate Box if a Member of a Group
(See
Instructions)
(a) o
(b) o
|
||
3.
|
SEC
Use Only
|
||
4.
|
Citizenship
or Place of Organization
Luxembourg
|
||
5.
|
Sole
Voting Power
0
|
||
Number
of
Shares
Beneficially
|
6.
|
Shared
Voting Power
0
|
|
Owned
by Each
Reporting
Person
With:
|
7.
|
Sole
Dispositive Power
0
|
|
8.
|
Shared
Dispositive Power
0
|
||
9.
|
Aggregate
Amount Beneficially Owned by Each Reporting Person
0
|
||
10.
|
Check
box if the Aggregate Amount in Row (9) Excludes
Certain
Shares (See
Instructions)
o
|
||
11.
|
Percent
of Class Represented by Amount in Row (9)
0%
(based on 94,774,187 shares of common stock outstanding as of November 7,
2007, as reported in the Issuer’s prospectus supplement filed
with the Securities and Exchange Commission November 19,
2007)
|
||
12.
|
Type
of Reporting Person (See Instructions)
CO
|
1.
|
Names
of Reporting Persons.
I.R.S.
Identification Nos. of above persons (entities only).
Sigma-Tau
Pharmaceuticals, Inc. On October 25, 2007, Sigma-Tau Pharmaceuticals, Inc.
was merged into Sigma-Tau Holding America, Inc., which survived and
changed its name to Sigma-Tau Pharmaceuticals, Inc.
|
||
2.
|
Check
the Appropriate Box if a Member of a Group
(See
Instructions)
(a) o
(b) o
|
||
3.
|
SEC
Use Only
|
||
4.
|
Citizenship
or Place of Organization
Nevada
|
||
5.
|
Sole
Voting Power
0
|
||
Number
of
Shares
Beneficially
|
6.
|
Shared
Voting Power
0
|
|
Owned
by Each
Reporting
Person
With:
|
7.
|
Sole
Dispositive Power
0
|
|
8.
|
Shared
Dispositive Power
0
|
||
9.
|
Aggregate
Amount Beneficially Owned by Each Reporting Person
0
|
||
10.
|
Check
box if the Aggregate Amount in Row (9) Excludes
Certain
Shares (See
Instructions)
o
|
||
11.
|
Percent
of Class Represented by Amount in Row (9)
0%
(based on 94,774,187 shares of common stock outstanding as of November 7,
2007, as reported in the Issuer’s prospectus supplement filed
with the Securities and Exchange Commission November 19,
2007)
|
||
12.
|
Type
of Reporting Person (See Instructions)
CO
|
Item
1(a).
|
Name
of Issuer:
|
Item
1(b).
|
Address
of Issuer's Principal Executive
Offices:
|
Item
2(a).
|
Name
of Person Filing:
|
Item
2(b).
|
Address
of Principal Business Office:
|
Item
2(c).
|
Citizenship:
|
Item
2(d).
|
Title
of Class of Securities:
|
Item
2(e).
|
CUSIP
Number:
|
Item
3.
|
If
this statement is filed pursuant to §§240.13d-1(b) or 240.13d-2(b) or (c),
check whether the person is a:
|
Item
4.
|
Ownership:
|
(a)
|
Amount
beneficially owned:
|
1,546,870
|
(b)
|
Percent
of class:
|
1.6%
|
(c)
|
Number
of shares as to which such person has:
|
|
(i) sole
power to vote or to direct the vote:
|
1,546,870
|
|
(ii) shared
power to vote or to direct the vote:
|
0
|
|
(iii)
sole power to dispose or to direct the disposition of:
|
1,546,870
|
|
(iv)
shared power to dispose or to direct the disposition of:
|
0
|
(a)
|
Amount
beneficially owned:
|
0
|
(b)
|
Percent
of class:
|
0%
|
(c)
|
Number
of shares as to which such person has:
|
|
(i) sole
power to vote or to direct the vote:
|
0
|
|
(ii) shared
power to vote or to direct the vote:
|
0
|
|
(iii)
sole power to dispose or to direct the disposition of:
|
0
|
|
(iv)
shared power to dispose or to direct the disposition of:
|
0
|
(a)
|
Amount
beneficially owned:
|
0
|
(b)
|
Percent
of class:
|
0%
|
(c)
|
Number
of shares as to which such person has:
|
|
(i) sole
power to vote or to direct the vote:
|
0
|
|
(ii) shared
power to vote or to direct the vote:
|
0
|
|
(iii) sole
power to dispose or to direct the disposition of:
|
0
|
|
(iv) shared
power to dispose or to direct the disposition of:
|
0
|
(a)
|
Amount
beneficially owned:
|
0
|
(b)
|
Percent
of class:
|
0%
|
(c)
|
Number
of shares as to which such person has:
|
|
(i) sole
power to vote or to direct the vote:
|
0
|
|
(ii) shared
power to vote or to direct the vote:
|
0
|
|
(iii)
sole power to dispose or to direct the disposition of:
|
0
|
|
(iv)
shared power to dispose or to direct the disposition of:
|
0
|
(a)
|
Amount
beneficially owned:
|
0
|
(b)
|
Percent
of class:
|
0%
|
(c)
|
Number
of shares as to which such person has:
|
|
(i) sole
power to vote or to direct the vote:
|
0
|
|
(ii) shared
power to vote or to direct the vote:
|
0
|
|
(iii)
sole power to dispose or to direct the disposition of:
|
0
|
|
(iv)
shared power to dispose or to direct the disposition of:
|
0
|
(a)
|
Amount
beneficially owned:
|
0
|
(b)
|
Percent
of class:
|
0%
|
(c)
|
Number
of shares as to which such person has:
|
|
(i) sole
power to vote or to direct the vote:
|
0
|
|
(ii) shared
power to vote or to direct the vote:
|
0
|
|
(iii)
sole power to dispose or to direct the disposition of:
|
0
|
|
(iv)
shared power to dispose or to direct the disposition of:
|
0
|
Item
5.
|
Ownership
of Five Percent or Less of a Class:
|
Item
6.
|
Ownership
of More than Five Percent on Behalf of Another
Person:
|
Item
7.
|
Identification
and Classification of the Subsidiary Which Acquired the Security Being
Reported on by the Parent Holding
Company:
|
Item
8.
|
Identification
and Classification of Members of the
Group:
|
Item
9.
|
Notice
of Dissolution of Group:
|
Item
10.
|
Certification:
|
A.
|
Joint
Filing Agreement dated January 12, 2007 by and among Paolo Cavazza,
Claudio Cavazza, Sigma Tau Finanziaria S.p.A., Sigma-Tau Pharmaceuticals,
Inc., Sigma Tau America S.A., Sigma-Tau Holding America, Inc. and Sigma
Tau International S.A.1
|
B.
|
Power
of Attorney, dated January 9, 2007, granted by Messrs. Dominique Audia and
Luca Checchinato, directors of Sigma-Tau International S.A., in favor of
Messrs. Gregg Lapointe and Don DeLillo2
|
C.
|
Power
of Attorney, dated January 9, 2007, granted by Messrs. Dominique Audia and
Luca Checchinato, directors of Sigma-Tau America S.A., in favor of Messrs.
Gregg Lapointe and Don DeLillo3
|
D.
|
Power
of Attorney, dated January 10, 2007, granted by Mr. Paolo Cavazza in favor
of Messrs. Antonio Nicolai and Maurizio Terenzi4
|
E.
|
Power
of Attorney, dated January 10, 2007, granted by Mr. Claudio Cavazza,
President of Sigma-Tau Finanziaria S.p.A., in favour of Messrs. Antonio
Nicolai and Maurizio Terenzi5
|
F.
|
Power
of Attorney, dated January 10, 2007, granted by Mr. Claudio Cavazza in
favor of Messrs. Antonio Nicolai and Maurizio Terenzi6
|
1
|
Incorporated
by reference to the Reporting Person’s Schedule 13G filed with the SEC on
January 12, 2007
|
2
|
Incorporated
by reference to the Reporting Person’s Schedule 13G filed with the SEC on
January 12, 2007.
|
3
|
Incorporated
by reference to the Reporting Person’s Schedule 13G filed with the SEC on
January 12, 2007.
|
4
|
Incorporated
by reference to the Reporting Person’s Schedule 13G filed with the SEC on
January 12, 2007.
|
5
|
Incorporated
by reference to the Reporting Person’s Schedule 13G filed with the SEC on
January 12, 2007.
|
6
|
Incorporated
by reference to the Reporting Person’s Schedule 13G filed with the SEC on
January 12, 2007.
|