Form 6-K
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C.
20549
Form 6-K
Report of Foreign Private Issuer
Pursuant to Rule 13a-16 or 15d-16
of the Securities Exchange Act of 1934
For the month of October
Commission File Number 000-31062
Oncolytics Biotech Inc.
(Translation of registrants name into
English)
Suite 210, 1167 Kensington Crescent NW
Calgary, Alberta, Canada T2N 1X7
(Address of principal executive offices)
Indicate by check mark whether the registrant files or will file annual reports
under cover Form 20-F or Form 40-F.
Indicate by check mark if the registrant is submitting the Form 6-K in paper as
permitted by Regulation S-T Rule 101(b)(1): o
Note: Regulation S-T Rule 101(b)(1) only permits the submission in paper of a
Form 6-K if submitted solely to provide an attached annual report to security
holders.
Indicate by check mark if the registrant is submitting the Form 6-K in paper as
permitted by Regulation S-T Rule 101(b)(7): o
Note: Regulation S-T Rule 101(b)(7) only permits the submission in paper of a
Form 6-K if submitted to furnish a report or other document that the registrant
foreign private issuer must furnish and make public under the laws of the
jurisdiction in which the registrant is incorporated, domiciled or legally
organized (the registrants home country), or under the rules of the home
country exchange on which the registrants securities are traded, as long as
the report or other document is not a press release, is not required to be and
has not been distributed to the registrants security holders, and, if
discussing a material event, has already been the subject of a Form 6-K
submission or other Commission filing on EDGAR.
Indicate by check mark whether by furnishing the information contained in this
Form, the registrant is also thereby furnishing the information to the
Commission pursuant to Rule 12g3-2(b) under the Securities Exchange Act of
1934.
If Yes is marked, indicate below the file number assigned to the registrant
in connection with Rule 12g3-2(b): 82 -
TABLE OF CONTENTS
SIGNATURES
Pursuant to the requirements of the Securities Exchange Act of 1934, the
registrant has duly caused this report to be signed on its behalf by the
undersigned, thereunto duly authorized.
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Oncolytics
Biotech Inc.
(Registrant) |
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Date: October 19, 2005 |
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By: |
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/s/ Doug Ball
Doug Ball
Chief Financial Officer |
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210, 1167 Kensington Crescent NW
Calgary, Alberta
Canada T2N 1X7 |
FOR IMMEDIATE RELEASE
Oncolytics Biotech Inc. Ends Patient Treatment in
Canadian Phase I Recurrent Malignant Glioma Clinical Trial
CALGARY, AB, October 19, 2005 - Oncolytics Biotech Inc. (Oncolytics) (TSX:ONC,
NASDAQ:ONCY) announced today that it has ended patient treatment in its Canadian Phase I clinical
trial investigating the use of REOLYSIN® to treat patients with recurrent malignant glioma. A total
of twelve patients were treated in the study at dosages of 107, 108, and
109 TCID50. A maximum tolerated dose was not reached over this dosage range
and REOLYSIN® appears to have been well tolerated by the patients. The principal investigator of
the trial, Dr. Peter Forsyth (University of Calgary and the Tom Baker Cancer Centre, Calgary,
Alberta) and Oncolytics will present further information on the trial when final results are
available.
We will continue investigating the use of REOLYSIN® as a monotherapy to treat patients with
recurrent malignant glioma in our U.S. malignant glioma clinical trial. The U.S. study employs an
alternative method of product delivery using product made with our current manufacturing process,
said Dr. Brad Thompson, President and CEO of Oncolytics. Our future plans are to investigate the
use of REOLYSIN® in Phase II studies for malignant glioma in combination with both
chemotherapeutics and radiation therapy.
Determination of the safety of REOLYSIN® was the primary purpose of this Canadian Phase I study.
The study examined the use of a single, intratumoural injection of REOLYSIN®, delivered using
imaging-guided surgery, in patients with malignant gliomas that had recurred despite other
treatments, including surgery and radiation therapy. After treatment with REOLYSIN®, the Phase I
patients are monitored and evaluated for safety for a period of six months. The Company previously
reported that REOLYSIN® appeared to be well tolerated when surgically delivered into the brain
during the treatment of the first six patients enrolled in the study.
About Oncolytics Biotech Inc.
Oncolytics is a Calgary-based biotechnology company focused on the development of REOLYSIN®, its
proprietary formulation of the human reovirus, as a potential cancer therapeutic. Oncolytics
researchers have demonstrated that the reovirus is able to selectively kill cancer cells and, in
vitro, kill human cancer cells that are derived from many types of cancer including breast,
bladder, prostate, pancreatic and brain tumours, and have also demonstrated successful cancer
treatment results in a number of animal models. Previous Phase I clinical trial results have
indicated that REOLYSIN® was well tolerated and that the reovirus demonstrated activity in tumours
injected with REOLYSIN®.
This press release contains forward-looking statements, within the meaning of Section 21E of
the Securities Exchange Act of 1934, as amended. Forward-looking statements, including the
Companys expectations related to the results of the Canadian Phase I recurrent malignant glioma
clinical trial and the US Phase 1/II trial investigating delivery of REOLYSIN® for recurrent
malignant gliomas, and the Companys belief as to the potential of REOLYSIN® as a cancer
therapeutic, involve known and unknown risks and uncertainties, which could cause the Companys
actual results to differ materially from those in the forward-looking statements. Such risks and
uncertainties include, among others, the availability of funds and resources to pursue research and
development projects, the efficacy of REOLYSIN® as a cancer treatment, the success and timely
completion of clinical studies and trials, the Companys ability to successfully commercialize
REOLYSIN®, uncertainties related to the research and development of pharmaceuticals, uncertainties
related to the regulatory process and general changes to the economic environment. Investors should
consult the Companys quarterly and annual filings with the Canadian and U.S. securities
commissions for additional information on risks and uncertainties relating to the forward looking
statements. Investors are cautioned against placing undue reliance on forward-looking statements.
The Company does not undertake to update these forward-looking statements.
FOR FURTHER INFORMATION PLEASE CONTACT:
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Oncolytics Biotech Inc. |
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The Equicom Group |
Dr. Brad Thompson |
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Joanna Longo |
210, 1167 Kensington Cr NW |
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20 Toronto Street |
Calgary, Alberta T2N 1X7 |
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Toronto, Ontario M5C 2B8 |
Tel: 403.670.7377 |
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Tel: 416.815.0700 ext. 233 |
Fax: 403.283.0858 |
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Fax: 416.815.0080 |
www.oncolyticsbiotech.com |
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jlongo@equicomgroup.com |
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The Investor Relations Group |
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RenMark Financial Communications |
John Nesbett or Damian McIntosh |
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John Boidman |
11 Stone Street, 3rd Floor |
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2080 Rene Levesque Blvd. W. |
New York, NY 10004 |
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Montreal, PQ H3H 1R6 |
Tel: 212.825.3210 |
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Tel: 514.939.3989 |
Fax: 212.825.3229 |
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Fax: 514.939.3717 |
dmcintosh@investorrelationsgroup.com |
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jboidman@renmarkfinancial.com |
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