UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C.  20549

                                    FORM 13F

                              FORM 13F COVER PAGE


                 Report for the Quarter Ended September 30, 2010



                          AMERICAN FINANCIAL GROUP, INC.
                 One East Fourth Street, Cincinnati, Ohio 45202
     -------------------------------------------------------------------------
     (Name and Address of Institutional Investment Manager Filing this Report)


                         Form 13F File Number:  28-4389


The institutional investment manager filing this report and the person by whom
it is signed hereby represent that the person signing the report is authorized
to submit it, that all information contained herein is true, correct and
complete, and that it is understood that all required items, statements,
schedules, lists, and tables, are considered integral parts of this form.

                                 Robert H. Ruffing
                     	   Vice President and Controller
                                   (513) 579-2144
                -----------------------------------------------
                (Name, Title and Phone Number of Person Signing
                 this Report on Behalf of Reporting Manager)



Signature:

/s/Robert H. Ruffing                  Cincinnati, Ohio         November 11, 2010
-------------------------------
Robert H. Ruffing
Vice President and Controller


Report Type:
     [X]  13F HOLDINGS REPORT.
     [ ]  13F NOTICE.
     [ ]  13F COMBINATION REPORT.














                            FORM 13F SUMMARY PAGE
                            ---------------------




Number of Other Included Managers:                         1
                                                      -----------

Form 13F Information Table Entry Total:                   72
                                                      -----------

Form 13F Information Table Value Total (thousands):     $481,605
                                                      -----------



Name and 13F file numbers of all Institutional Investment Managers with respect
to which this schedule is filed (other than American Financial Group, Inc.):

    Number    13F File Number         Name of Subsidiary
    ------    ---------------         ------------------------------------

       1.          28-498             Great American Insurance Company






































                                                       FORM 13F INFORMATION TABLE


                                                             Column 4:   Column 5:                               Column 8:
                                   Column 2:                  Market     Shares or    Column 6: Column 7:    Voting Authority
        Column 1:                  Title of       Column 3:    Value     Principal   Investment    Other ---------------------------
     Name of Issuer                  Class          CUSIP     (000's)      Amount    Discretion Managers    Sole    Shared    None
     --------------             ---------------- ----------- ---------  ------------ ---------- -------- ---------- ------ ---------


HOLDINGS OF GREAT AMERICAN INSURANCE COMPANY
--------------------------------------------
                                                                                                 
AMERICAN COMMERCIAL LINES        COM PAR $0.01   025195 40 5     1,959      70,250SH   Defined     1         70,250
AMERICAN RAILCAR INDS INC             COM        02916P 10 3     1,066      68,000SH   Defined     "         68,000
ANWORTH MORTGAGE ASSET CP             COM        037347 10 1       891     125,000SH   Defined     "        125,000
BANK OF AMERICA CORPORATION           COM        060505 10 4     1,417     108,120SH   Defined     "        108,120
CALAMP CORP                           COM        128126 10 9       359     139,750SH   Defined     "        139,750
CHEVRON CORP NEW                      COM        166764 10 0    10,034     123,800SH   Defined     "        123,800
COCA COLA CO                          COM        191216 10 0     9,919     169,500SH   Defined     "        169,500
COMCAST CORPORATION NEW              CL A        20030N 10 1     7,051     390,000SH   Defined     "        390,000
DELTA AIR LINES INC DEL             COM NEW      247361 70 2       154      13,239SH   Defined     "         13,239
DISH NETWORK CORP                    CL A        25470M 10 9       724      37,675SH   Defined     "         37,675
ECHOSTAR CORP                        CL A        278768 10 6       473      24,786SH   Defined     "         24,786
FLAGSTAR BANCORP INC                COM NEW      337930 50 7        30      16,500SH   Defined     "         16,500
FULL HOUSE RESORTS INC		      COM        359678 10 9       111      35,331SH   Defined     "         35,331
HEINZ H J CO                          COM        423074 10 3     9,557     201,750SH   Defined     "        201,750
INSTEEL INDUSTRIES INC                COM        45774W 10 8       221      24,609SH   Defined     "         24,609
INTEL CORP                            COM        458140 10 0     9,456     492,500SH   Defined     "        492,500
INTERNATIONAL BUSINESS MACHS          COM        459200 10 1    10,027      74,750SH   Defined     "         74,750
JOHNSON & JOHNSON                     COM        478160	10 4     9,728     157,000SH   Defined	   "        157,000
KELLOGG CO                            COM        487836 10 8     9,438     186,850SH   Defined     "        186,850
KIMBERLY CLARK CORP                   COM        494368 10 3     9,530     146,500SH   Defined     "        146,500
KRAFT FOODS INC                      CL A        50075N 10 4     9,574     310,250SH   Defined     "        310,250
LOCKHEED MARTIN CORP                  COM        539830 10 9     1,622      22,750SH   Defined     "         22,750
MYR GROUP INC DEL                     COM        55405W 10 4     6,304     384,615SH   Defined     "        384,615
MCDONALDS CORP                        COM        580135 10 1     9,649     129,500SH   Defined     "        129,500
MERCK & CO INC NEW                    COM        58933Y 10 5     8,982     244,000SH   Defined     "        244,000
MICROSOFT CORP                        COM        594918 10 4     9,539     389,500SH   Defined     "        389,500
MOTRICITY INC                         COM        620107 10 2       991      82,525SH   Defined     "         82,525
NATIONAL INTERSTATE CORP              COM        63654U 10 0   222,054  10,200,000SH   Defined     "     10,200,000
O CHARLEYS INC                        COM        670823 10 3       212      29,500SH   Defined     "         29,500
OMEROS CORP                           COM        682143 10 2       744     102,040SH   Defined     "        102,040
PATTERSON UTI ENERGY INC              COM        703481 10 1       683      40,000SH   Defined     "         40,000
PEPSICO INC                           COM        713448 10 8     9,637     145,050SH   Defined     "        145,050
PFIZER INC                            COM        717081 10 3     4,979     290,000SH   Defined     "        290,000
RAYTHEON CO                         COM NEW      755111 50 7     1,577      34,500SH   Defined     "         34,500
3M CO                                 COM        88579Y 10 1     9,928     114,500SH   Defined     "        114,500
TIME WARNER INC                     COM NEW      887317 30 3       267       8,716SH   Defined     "          8,716
TORTOISE ENERGY CAP CORP              COM        89147U 10 0       667      25,800SH   Defined     "         25,800
VIRGIN MEDIA INC                      COM        92769L 10 1    17,014     737,807SH   Defined     "        737,807
WALGREEN CO                           COM        931422 10 9     8,258     246,500SH   Defined     "        246,500







HOLDINGS OF OTHER ENTITIES
EACH HAVING LESS THAN
$100 MILLION IN 13F SECURITIES
------------------------------
ACE LTD                               SHS        H0023R 10 5     3,670      63,000SH    Sole                 63,000
AMERICAN COMMERCIAL LINES        COM PAR $0.01   025195 40 5     2,377      85,250SH   Defined               85,250
AMERICAN RAILCAR INDS INC             COM        02916P 10 3     1,060      67,581SH   Defined               67,581
ANWORTH MORTGAGE ASSET CP             COM        037347 10 1       891     125,000SH   Defined              125,000
BANK OF AMERICA CORPORATION           COM        060505 10 4     4,239     323,480SH   Defined              323,480
BERKLEY W R CORP                      COM        084423 10 2     3,167     117,000SH    Sole                117,000
CALAMP CORP                           COM        128126 10 9       362     140,750SH   Defined              140,750
CHUBB CORP                            COM        171232 10 1     4,046      71,000SH    Sole                 71,000
DELTA AIR LINES INC DEL             COM NEW      247361 70 2       176      15,097SH   Defined               15,097
DEX ONE CORP                          COM        25212W 10 0       132      10,772SH   Defined               10,772
DISH NETWORK CORP                    CL A        25470M 10 9     1,086      56,512SH   Defined               56,512
EATON VANCE TAX MNG GBL DV E          COM        27829F 10 8       438      40,000SH   Defined     1         40,000
ECHOSTAR CORP                        CL A        278768 10 6       709      37,179SH   Defined               37,179
FLAGSTAR BANCORP INC                COM NEW      337930 50 7        30      16,500SH   Defined               16,500
FULL HOUSE RESORTS INC		      COM        359678 10 9        99      31,617SH   Defined               31,617
INSTEEL INDUSTRIES INC                COM        45774W 10 8       200      22,216SH   Defined               22,216
ISHARES TR                        MSCI EAFE IDX  464287 46 5     2,362      43,000SH   Defined     1         43,000
ISHARES TR                       DJ US TELECOMM  464287 71 3       208       9,550SH   Defined     "          9,550
KEYCORP NEW                           COM        493267 10 8       416      52,222SH   Defined     "         52,222
MANAGED HIGH YIELD PLUS FD I          COM        561911 10 8        23      10,000SH   Defined     "         10,000
MERCK & CO INC NEW                    COM        58933Y 10 5       736      20,000SH   Defined               20,000
MOTRICITY INC                         COM        620107 10 2     1,487     123,787SH   Defined              123,787
O CHARLEYS INC                        COM        670823 10 3       321      44,654SH   Defined               44,654
OMEROS CORP                           COM        682143 10 2     1,116     153,061SH   Defined              153,061
PATTERSON UTI ENERGY INC              COM        703481 10 1       683      40,000SH   Defined               40,000
PFIZER INC                            COM        717081 10 3       343      20,000SH   Defined               20,000
POWERSHARES ETF TRUST            DYNAMIC MKT PT  73935X 10 4       960      24,400SH   Defined     1         24,400
POWERSHARES ETF TRUST            HI YLD EQ DVDN  73935X 30 2       178      21,300SH   Defined     "         21,300
SPDR S&P 500 ETF TR                 TR UNIT      78462F 10 3     5,022      44,000SH   Defined     "         44,000
SELECT SECTOR SPDR TR            SBI CONS STPLS  81369Y 30 8       977      35,060SH   Defined     "         35,060
SELECT SECTOR SPDR TR            SBI INT-UTILS   81369Y 88 6       235       7,500SH   Defined     "          7,500
TORTOISE ENERGY CAP CORP              COM        89147U 10 0     2,221      85,900SH   Defined               85,900
VIRGIN MEDIA INC                      COM        92769L 10 1    26,809   1,162,588SH   Defined            1,162,588


                                                             ----------
                                 REPORT TOTAL                 $481,605
                                                             ==========