FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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(Print or Type Responses)

1. Name and Address of Reporting Person * HERLIHY WALTER C   2. Issuer Name and Ticker or Trading Symbol REPLIGEN CORP [RGEN] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) __X__ Director _____ 10% Owner __X__ Officer (give title below) _____ Other (specify below) PRESIDENT, CEO (Last) (First) (Middle) C/O REPLIGEN CORPORATION, 41 SEYON STREET SUITE 100, BUILDING 1 3. Date of Earliest Transaction (Month/Day/Year) 12/13/2007 (Street) WALTHAM, MA 02453 4. If Amendment, Date Original Filed(Month/Day/Year) 12/14/2007 6. Individual or Joint/Group Filing(Check Applicable Line) _X_ Form filed by One Reporting Person ___ Form filed by More than One Reporting Person (City) (State) (Zip) Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned

1.Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 12/13/2007   S(7)   2,600 D (1) $ 6.15 499,603 D   Common Stock 12/13/2007   S(8)   16,850 D (2) $ 6.14 482,753 D   Common Stock 12/13/2007   S(9)   8,850 D (3) $ 6.13 473,903 D   Common Stock 12/13/2007   S(10)   12,033 D (4) $ 6.12 461,870 D   Common Stock 12/13/2007   S(11)   6,467 D (5) $ 6.11 455,403 D   Common Stock 12/13/2007   S(12)   600 D (6) $ 6.105 454,803 D   Common Stock 12/13/2007   S(13)   2,600 D $ 6.1 452,203 D

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)

1. Title of Derivative Security (Instr. 3)

2. Conversion or Exercise Price of Derivative Security

3. Transaction Date (Month/Day/Year)

3A. Deemed Execution Date, if any (Month/Day/Year)

4. Transaction Code (Instr. 8)

5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5)

6. Date Exercisable and Expiration Date (Month/Day/Year)

7. Title and Amount of Underlying Securities (Instr. 3 and 4)

8. Price of Derivative Security (Instr. 5)

9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)

10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)

11. Nature of Indirect Beneficial Ownership (Instr. 4)

Code

V

(A)

(D)

Date Exercisable

Expiration Date

Title

Amount or Number of Shares

Reporting Owners

Reporting Owner Name / Address	Relationships
	Director	10% Owner	Officer	Other
HERLIHY WALTER C C/O REPLIGEN CORPORATION 41 SEYON STREET SUITE 100, BUILDING 1 WALTHAM, MA 02453	X		PRESIDENT, CEO

Signatures

Walther Herlihy		12/19/2007
**Signature of Reporting Person		Date

Explanation of Responses:

*	If the form is filed by more than one reporting person, see Instruction 4(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1)	Incorrectly reported these securities as acquired, when in fact they were disposed of as a sale.
(2)	Incorrectly reported these securities as acquired, when in fact they were disposed of as a sale.
(3)	Incorrectly reported these securities as acquired, when in fact they were disposed of as a sale.
(4)	Incorrectly reported these securities as acquired, when in fact they were disposed of as a sale.
(5)	Incorrectly reported these securities as acquired, when in fact they were disposed of as a sale.
(6)	Incorrectly reported these securities as acquired, when in fact they were disposed of as a sale.
(7)	Incorrectly reported this sales transaction code as a "D", when in fact it was an open market sale.
(8)	Incorrectly reported this sales transaction code as a "D", when in fact it was an open market sale.
(9)	Incorrectly reported this sales transaction code as a "D", when in fact it was an open market sale.
(10)	Incorrectly reported this sales transaction code as a "D", when in fact it was an open market sale.
(11)	Incorrectly reported this sales transaction code as a "D", when in fact it was an open market sale.
(12)	Incorrectly reported this sales transaction code as a "D", when in fact it was an open market sale.
(13)	Incorrectly reported this sales transaction code as a "D", when in fact it was an open market sale.
Remarks: Incorrectly reported the open market sale of the securites as a disposition to issuer in Table 1, Block 3.  Incorrectly reported sale of securities as "Securities Acquired", instead of "Disposed Of Securities" in Table 1, Block 4.

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